Grant ID RP170500
Awarded On August 16, 2017
Title Development of next generation steroid receptor coactivator small molecule inhibitors as novel agents to target therapy-resistant breast cancer
Program Academic Research
Award Mechanism Bridging the Gap: Early Translational Research Awards
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Bert O'Malley
Cancer Sites Breast
Contracted Amount $914,006
Lay Summary

Two overarching challenges for current breast cancer treatment are resistance to endocrine therapy in estrogen receptor positive (ER+) breast cancer and tumor metastasis in triple negative breast cancer (TNBC). The objective of this proposal is to develop a novel targeted therapy to address these clinical challenges by inhibiting steroid receptor coactivator 3 (SRC-3) using small molecule inhibitors (SMIs). Our previous work demonstrated that SRC-3 is a master regulator of cellular growth and development which sits at the nexus of many intracellular signaling pathways critical for cancer formation and proliferation. Inhibition of SRC-3 can significantly reduce cancer cell proliferation, moti...

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