Grant ID RP170126
Awarded On November 16, 2016
Title A Novel Pathway to Reduce BRCA1-Associated Breast Cancer Risk
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Health Science Center at San Antonio
Principal Investigator/Program Director Victor Jin
Cancer Sites Breast
Contracted Amount $900,000
Lay Summary

Breast cancer risk is significantly elevated for women who carry germ-line mutations in the tumor suppressor gene BRCA1. While breast tissue is composed of multiple cell types and all of them inherit the same BRCA1 mutation in mutation-carrying women, BRCA1-associated breast cancer specifically originates from a cell type called luminal progenitor cells. BRCA1 plays a critical role in repair of damaged DNA, which is universally important for all proliferating cells in the body. Thus, it remains a puzzle as to why breast luminal cells in BRCA1 mutation carriers are most susceptible to tumor development. We recently uncovered an antagonizing relationship between BRCA1 and a dedicated transc...

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