|Awarded On||November 16, 2016|
|Title||Molecular Epidemiology And Somatic Alterations Driving Acute Lymphoblastic Leukemia In Down Syndrome|
|Award Mechanism||Individual Investigator Research Awards for Cancer in Children and Adolescents|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Karen Rabin|
Down syndrome results from an extra copy of chromosome 21 and is one of the most common genetic syndromes. Children with Down syndrome have a 10-20 fold increased risk of developing acute lymphoblastic leukemia (ALL), the most common childhood cancer. Even though the success rate today for treating childhood leukemia is high, children with Down syndrome and ALL suffer poorer survival due to increased risk of both relapse and fatal treatment-related complications. The reason for the increased risk of ALL in children with Down syndrome is unknown. Several recent studies have identified genetic risk factors associated with an increased risk of ALL in the general population. In this project, we...