Grant ID RP170040
Awarded On November 16, 2016
Title Exploiting DNA repair defects using intensity modulated proton therapy
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Gabriel Sawakuchi
Cancer Sites All Sites
Contracted Amount $899,889
Lay Summary

In the United States and specifically Texas, about one third of the population will be diagnosed with cancer in their lifetime. More than half of patients with solid tumors are treated with radiotherapy. Our research aims to improve cancer treatments by combining one of the most advanced techniques in radiotherapy, intensity modulated proton therapy (IMPT), with newly developed molecularly targeted drugs (MTDs). The combination of IMPT and MTD has the potential to reduce side effects to healthy tissues and to escalate the radiation kill effect to the tumor volume. Moreover, it has the potential to reduce treatment time, leading to cost reductions. The rationale for using proton therapy beam...

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