Grant ID RP160866
Awarded On May 18, 2016
Title Renal Clearable Nanodelivery System for Triple Negative Breast Cancer Therapy
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas at Dallas
Principal Investigator/Program Director Jie Zheng
Cancer Sites Breast
Contracted Amount $200,000
Lay Summary

Chemotherapy patients suffer from a variety of side effects such as pain, fever, numbness and nausea, mainly due to accumulation of anticancer drugs in normal tissues and healthy organs. Therefore, how to diminish such side effects without impacting the battle against the tumor has been a long-term challenge in cancer thermotherapy. In this proposal, we plan to develop a class of renal clearable near infrared (NIR) emitting gold nanoparticles (AuNPs) that can effectively deliver anticancer drugs to triple negative breast tumor that currently is hard to be treated due to lack of key receptors, retain drug molecules in the tumor for long period of time, release them in tumor sites, and more im...

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