Grant ID RP160806
Awarded On May 18, 2016
Title Development of high throughput technology to identify drugs for muscle wasting during cancer
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization Texas Tech University
Principal Investigator/Program Director Siva Vanapalli
Cancer Sites Colorectal, Lung and Bronchus, Pancreas, Small Intestine
Contracted Amount $199,995
Lay Summary

A significant number of cancer patients experience muscle wasting, a phenomenon that is clinically referred to as cachexia. Due to a substantial loss in muscle mass and strength, cachexia presents a major quality of life problem for cancer patients. Cachexia patients suffer from fatigue, fitness loss, lethargy, psychological burden, and have difficulty battling the side effects of chemotherapy. Increased feeding does not improve muscle mass and strength due to accelerated degradation of muscle proteins. Importantly, one-third of the cancer deaths are attributed to cachexia and there are no approved drugs for its treatment. In this proposal, we seek to develop a high throughput technology for...

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