Grant ID RP160577
Awarded On November 19, 2015
Title A novel function of Itch in controlling IL-17-induced inflammation in colon cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Venuprasad K Poojary
Cancer Sites Colorectal
Contracted Amount $431,523.62
Award Transfer Information

Previous Organization: Baylor Research Institute

Expended at Previous Organization: $468,476.38

Lay Summary

Approximately 124,000 new cases and 49,700 deaths are expected from colorectal cancer (CRC) this year alone in the US. Many factors cause CRC including genetic mutations (changes in the DNA), high-fat diet, and inflammation. Recent studies suggest that the microorganisms in the intestine trigger interleukin-17 (IL-17), a type of protein that helps the immune system keep gut bacteria under control. However, when overproduced it can enhance cancer-promoting inflammation. IL-17 expression is very high in CRC patients. Understanding the detailed molecular mechanisms that naturally inhibit IL-17 production and inflammation in the colon is essential to develop more effective preventive and therape...

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