Grant ID RP160319
Awarded On November 19, 2015
Title Role of PARP-1 in Estrogen Receptor Enhancer Function and Gene Regulation Outcomes in Breast Cancers
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director W. Lee Kraus
Cancer Sites Breast
Contracted Amount $884,315
Lay Summary

Breast cancer is the second leading cause of cancer-related mortality in women, with a 1 in 8 lifetime of risk for women in the United States. A key hurdle in developing better treatments for breast cancers is a lack of understanding of the mechanisms that promote the growth of breast cancer cells, and why some breast cancers grow in response to estrogens, while others do not. Drugs that target PARP-1, a protein involved in many important cellular functions, have shown promise and may be useful for treating estrogen receptor alpha (ERa)-positive breast cancers. In this regard, we have been studying the interplay between ERa and PARP-1 in breast cancers. Specifically, we are focusing on th...

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