Grant ID RP160307
Awarded On November 19, 2015
Title Targeting Metastatic Pathways
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Lance S Terada
Cancer Sites Lung and Bronchus
Contracted Amount $647,866
Lay Summary

Over 90% of cancer-related deaths are due to metastasis and are not from the primary tumor. Presently, however, no treatment options are specific for metastatic sites. In large part, this lack of therapeutic development has been due to the complex and multi-step nature of tumor cell metastasis, which requires multiple genes to be up- or down-regulated. The principal aim of this grant is to explore one particular approach to intervening in metastatic tumor behavior through targeting a “master controller” of such behavior. In recent years, DNA mutations have been found to work in concert with much more widespread changes in cancer cells’ chromatin (DNA+surrounding proteins). Such “epigene...

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