Grant ID RP160268
Awarded On November 19, 2015
Title DNA damage-induced small non-coding RNAs: mechanism and their role in cancer development
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Yi Liu
Cancer Sites All Sites
Contracted Amount $900,000
Lay Summary

DNA damage generated spontaneously or induced by environmental agents, when is not appropriately repaired, is the basis for the initiation of most tumors due to the activation and deregulation of genes promoting cancer and/or the loss of function of tumor-suppressing genes. Therefore, proper DNA repair after DNA damage is crucial for the prevention of cancer development. DNA damage is known to trigger a conserved DNA damage response from fungi to man that can detect the damage, delay cell proliferation and repair the damage. Understanding how this process occurs and how it is regulated will provide mechanistic insights into future design of cancer prevention and therapeutic approaches. We r...

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