Grant ID RP160255
Awarded On November 19, 2015
Title Structural and Functional Analyses of the Spindle Checkpoint
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Xuelian Luo
Cancer Sites All Sites
Contracted Amount $900,000
Lay Summary

The spindle checkpoint ensures the fidelity of chromosome segregation during mitosis and meiosis. Studies in mouse models have firmly established that malfunction of the spindle checkpoint leads to chromosome missegregation and aneuploidy, which can result in tumorigenesis, premature aging, and other defects. Several spindle checkpoint genes, including Bub1, are mutated in human cancers, albeit with low frequency. Their expression is regulated by tumor suppressors and oncogenes and is frequently altered in cancer cells. This proposal investigates the basic molecular mechanisms of chromosome segregation in human cells, with a focus on the enigmatic roles and regulation of the checkpoint k...

Read More