Grant ID RP160054
Awarded On November 19, 2015
Title The CTC Circulator Phenotype: Insights into Mechanisms of Breast Cancer Dormancy
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Dario Marchetti
Cancer Sites Brain and Other Nervous System, Breast
Contracted Amount $884,332
Lay Summary

Breast cancer brain metastasis (BCBM) is the most feared consequence of breast cancer with Circulating Tumor Cells (CTCs) being the essential pre-condition for BCBM to occur. CTCs are shed into the vasculature, circulate and survive in the blood, arrest/adhere at distant organ sites, and extravasate at the target organs to generate metastasis. Importantly, higher than 67% of deaths in breast cancer patients occur after a 5-year survival mark and residual disease can be dormant for periods longer than 20 years. The patients are asymptomatic because CTCs appear to become dormant and are undetectable by clinical tools. Further, rates of CTC survival can be highly variable, lasting less few...

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