| Grant ID | RP120316 |
| Awarded On | November 02, 2011 |
| Title | CBM complex-mediated signaling pathways as potential therapeutic targets for EGFR-induced cancer |
| Program | Academic Research |
| Award Mechanism | Individual Investigator |
| Institution/Organization | The University of Texas M.D. Anderson Cancer Center |
| Principal Investigator/Program Director | Xin Lin |
| Cancer Sites | All Sites |
| Contracted Amount | $915,974 |
| Lay Summary |
Mutations and over-expression of Epidermal Growth Factor Receptor (EGFR), a type receptor that controls cell growth, are associated with tumorigenesis of various cancers. This aberrant expression of EGFR is found to induction of a family of transcription factors, NF-kB, which controls cell proliferation, survival, and migration. In this proposal, we will determine the requirement of a protein complex in mediating EGFR-induced NF-kB activation and EGFR-induced tumorigenesis. Results from this study will provide molecular insights for new therapeutic approaches against various cancers. |