| Grant ID | RP100718 |
| Awarded On | January 20, 2010 |
| Title | Development of small molecules mimicking pro-apoptotic proteins for treating prostate cancer |
| Program | Academic Research |
| Award Mechanism | Individual Investigator |
| Institution/Organization | The University of Texas at Dallas |
| Principal Investigator/Program Director | Jung-Mo Ahn |
| Cancer Sites | Prostate |
| Contracted Amount | $886,693 |
| Lay Summary |
Prostate cancer is the second leading cause of cancer-related death in men in US and the majority of mortality is due to the recurrent castration-resistant prostate cancer. Although the current chemotherapeutic treatments for this advanced prostate cancer generally improve the quality of life of patients, curative regiment is not available yet. It is found that castration-resistant prostate cancer derived from cancer stem cell exhibits radio- or chemo-resistant phenotype. The immortality and resistance acquired by cancer stem cell appear to be highly relevant to the elevated expression of anti-apoptotic proteins associated with castration-resistant prostate cancer. Thus, targeting anti-a... |