| Grant ID | RP100473 |
| Awarded On | January 20, 2010 |
| Title | Identification of selective modifiers of crypt stem cells the cells of origin of intestinal cancer |
| Program | Academic Research |
| Award Mechanism | High Impact/High Risk |
| Institution/Organization | Texas Agrilife Research |
| Principal Investigator/Program Director | Robert S Chapkin |
| Cancer Sites | Colorectal |
| Contracted Amount | $199,894 |
| Lay Summary |
Adult stem cells play an important role in intestinal tissue renewal and regeneration following injury. Evidence also suggests that intestinal crypt stem cells are the cells-of-origin of intestinal cancer. Recently, Lgr5 has been identified as a small intestine and colon stem cell marker. Therefore, it is now possible to visualize stem cells and examine their behavior in the context of cancer prevention. We will use novel stem cell-specific mouse models to examine the effects of colon cancer disease progression on gene expression in colon crypt stem cells following diet, carcinogen and chronic inflammation exposure. In principle, the application of stem cell screening experiments will f... |