Grant ID DP150127
Awarded On November 19, 2015
Title Engineered AXL Decoy Receptor for Treatment of AML & Solid Tumors
Program Product Development Research
Award Mechanism New Company Product Development Award
Institution/Organization Aravive Biologics, Inc.
Principal Investigator/Program Director Amato Giaccia
Cancer Sites Leukemia, Ovary, Pancreas
Contracted Amount $20,000,000
Lay Summary

Ruga Corporation is a late preclinical stage pharmaceutical company developing Ruga-S6, an engineered decoy soluble AXL receptor, for targeted therapy against acute myeloid lymphoma (AML) and certain solid tumor indications including ovarian, pancreatic, and breast cancer.

AML is a hematologic cancer affecting both pediatric and adult patients. While the pediatric population is small (~800), over 18,000 adults are diagnosed in the US annually, with the majority of these patients over 65. Based on 1996-2002 SEER statistics, the 5-year survival rate for adults older than 65 diagnosed with AML was a mere 4.3%. In the past 20 years, there has been little improvement in overall survival for AML...

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