Grant ID RR240016
Awarded On February 21, 2024
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization The University of Texas Health Science Center at San Antonio
Principal Investigator/Program Director Yu Luan
Cancer Sites Childhood and Adolescent, Leukemia
Contracted Amount $2,000,000
Summary of Goals and Objectives

Acute lymphoblastic leukemia (ALL) remains the most common pediatric cancer in the United States. In particular, Philadelphia chromosome-like ALL (Ph-like ALL), a major ALL subtype that is characterized by poor treatment outcomes and high relapse rate, disproportionately affects the Hispanic communities in South Texas. We are a leading research group in the application of state-of-the-art genomic analytical tools to define the molecular etiology of Ph-like ALL and to explain why this disease is often poorly responsive to standard-of-care treatment regimens and associated with a high relapse rate. Importantly, our work has revealed how an inherited mutation in the GATA3 gene, which is central...

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