Grant ID RR230050
Awarded On August 16, 2023
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization The University of Texas at Austin
Principal Investigator/Program Director Zunlong Ke
Cancer Sites Gallbladder, Liver and Intrahepatic Bile Duct
Contracted Amount $2,000,000
Summary of Goals and Objectives

Liver cancer is a significant health concern associated with viral hepatitis, particularly hepatitis virus type B (HBV) and type C (HCV). The primary aim of this research proposal is to address a critical gap in liver cancer biology research by employing state-of-the-art cryo-electron tomography (cryo-ET) coupled with advanced computational analysis to investigate the molecular architecture of intact virions at near-atomic resolution and visualize replication intermediates within infected cells and liver cancer biopsies. This will reveal novel mechanistic insights into the key questions of cancer-causing viral biology, particularly the structure, distribution, and conformational states of he...

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