Grant ID RR230040
Awarded On August 16, 2023
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Graham Erwin
Cancer Sites All Sites
Contracted Amount $2,000,000
Summary of Goals and Objectives

The cancer genome is characterized by a myriad of genetic alterations that promote its growth and survival. In 5% of cancers, expansions and contractions at repetitive regions called short tandem repeat sequences lead to microsatellite instability. Although variations in TR sequences are implicated in over 40 human diseases, they remain underexplored in cancer due to the limitations of conventional bioinformatic tools. Our recent work identified recurrent repeat expansions (rREs) as an unexplored source of genetic variation in cancer (Erwin et al., Nature 2023). A comprehensive understanding of repeat variation in cancer is essential for developing novel TR-targeting therapeutics. In this a...

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