|Awarded On||August 18, 2021|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||Texas A&M Engineering Experiment Station|
|Principal Investigator/Program Director||Jason George|
|Cancer Sites||Leukemia, Lymphoma|
|Summary of Goals and Objectives||
Objective: The rationale for the proposed research is the need to better understand the extent to which cancer populations adopt active immune evasion strategies to evade T cell recognition in the setting of allogeneic CD8+ T cell immunotherapy. We currently lack a theoretical framework for cancer T cell evasion.
Therefore, the objective of this research is to develop a mathematical model to quantify the degree to which cancer populations employ adaptive, immune-specific evasion strategies, to apply this model to experimental data detailing cancer immune recognition and evasion, and to propose model-predicted, optimized hematopoietic stem cell transplant (HSCT) strategies in the setting of a...