|Awarded On||May 19, 2021|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||The University of Texas at Austin|
|Principal Investigator/Program Director||Cassandra Callmann|
|Cancer Sites||Gallbladder, Liver and Intrahepatic Bile Duct|
|Summary of Goals and Objectives||
The goal of the proposed work is to develop a new strategy for targeting hepatocellular carcinoma (HCC) tumors with high specificity, as a means of simultaneously delivering immunotherapeutic cargo and reprogramming the tumor immune landscape.
Galectin-3 (Gal-3) is a carbohydrate-binding protein that is highly overexpressed by HCC tumors and is correlated with poor prognosis. Moreover, Gal-3 binds to the surface of T cells and suppresses their tumoricidal action in tumors, leading to tumor immune escape. Herein, carbohydrate-polymer conjugates (CPCs) that bind to Gal-3 with high affinity in the tumor microenvironment will be developed and synthesized to include immunotherapeutic moieties alo...