|Awarded On||August 19, 2020|
|Title||Recruitment of Established Investigators|
|Award Mechanism||Recruitment of Established Investigators|
|Institution/Organization||The University of Texas Health Science Center at San Antonio|
|Principal Investigator/Program Director||David Gius|
|Cancer Sites||Breast, Gallbladder, Liver and Intrahepatic Bile Duct, Prostate|
|Summary of Goals and Objectives||
Our work addresses a fundamental issue in oncology, namely, that age represents a strong cancer risk factor. We focus on the biology of the sirtuin (SIRT) gene family and have developed murine models connecting the organismal physiology of aging and metabolic bioenergetics to carcinogenesis and tumor cell resistance. Dysregulation of antioxidant and energy regulating enzymes leads to perturbations in metabolic homeostasis and the accumulation of oxidized metabolites and reactive oxygen species that adversely affect cellular metabolism.
My laboratory has focused on understanding cell and mitochondrial networks that help maintain metabolic homeostasis and that, when disrupted, trigger early ev...