|Awarded On||August 19, 2020|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Bruno Di Stefano|
|Cancer Sites||Leukemia, Lung and Bronchus|
|Summary of Goals and Objectives||
Post-transcriptional mechanisms have the potential to influence complex changes in gene expression, yet their role in regulating tumor initiation and progression remains largely unexplored.
The goal of my research is to understand how post-transcriptional mechanisms govern self-renewal, differentiation, and tumorigenicity of cancer stem cells in diverse contexts. During my postdoctoral work, I identified the RNA processing protein Nudt21, as a crucial regulator of cellular reprogramming. Nudt21 stabilizes cell identity by directing alternative polyadenylation (APA), which generates distinct 3’ UTR isoforms for a given transcript by using different polyA sites. Additionally, I recently uncove...