|Awarded On||May 20, 2020|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Eric Van Nostrand|
|Cancer Sites||All Sites|
|Summary of Goals and Objectives||
Rewiring of RNA processing and translation is one of the most common hallmarks of cancer. Indeed, systematic proteogenomics cancer initiatives (ex. CPTAC) demonstrate that RNA levels frequently do not correlate (nor explain) protein levels and function in patient tumors and cancer models. This has major consequences for both our understanding of the (de)regulation of gene expression in cancer as well as precision cancer diagnosis and treatment. However, the molecular mechanisms that underpin deregulated RNA processing and translation in cancer are poorly understood.
In this proposal, I describe the development of a research laboratory in the Therapeutic Innovation Center at the Baylor Colleg...