| Grant ID | RR200007 |
| Awarded On | November 20, 2019 |
| Title | Recruitment of First-Time, Tenure-Track Faculty Members |
| Program | CPRIT Scholar |
| Award Mechanism | Recruitment of First-Time, Tenure-Track Faculty Members |
| Institution/Organization | The University of Texas Southwestern Medical Center |
| Principal Investigator/Program Director | Benjamin Drapkin |
| Cancer Sites | Lung and Bronchus |
| Contracted Amount | $2,000,000 |
| Summary of Goals and Objectives |
Small cell lung cancer (SCLC) afflicts more than 30,000 patients per year and is rapidly fatal in 95% of cases, with median survival of less than one year. Although untreated SCLC is highly responsive to first-line chemotherapy, benefit is temporary and following relapse, resistance often extends to a broad spectrum of DNA damaging agents. Also, investigational therapies in clinical trials are often confounded by the same cross-resistance that hinders standard second-line agents. Although important, cross-resistance is difficult to study experimentally, as it requires a model system that faithfully reproduces clinical out... |