Grant ID RP240501
Awarded On August 21, 2024
Title Delivering Immunotherapy more effectively to glioblastoma with a "magnetic switch"
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas at Dallas
Principal Investigator/Program Director Zhenpeng Qin
Cancer Sites Brain and Other Nervous System
Contracted Amount $250,000
Lay Summary

Glioblastoma, the most common adult brain tumor, is among the deadliest of all solid tumors with a median survival of 14.6 months. This status has not changed for over ten years despite intense therapeutic efforts. A unique and major challenge in treating brain tumors is the difficulty in delivering effective drugs across the blood-brain barrier (BBB), which protects the brain by preventing many substances in the blood from entering the brain tissue. This is also the case for antibodies that target immune checkpoints, in which the CNS penetration is limited. The main goal of this research is to invent a magnetic switch that can open up this barrier and let the medicine through, named as Mag...

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