|Awarded On||February 15, 2023|
|Title||Changes in Tumor Microenvironment that Promote Cachexia|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Rodney Infante|
|Cancer Sites||Colorectal, Lung and Bronchus|
Cancer cachexia is a devastating wasting syndrome consisting of significant fat and muscle loss observed in 50% of all cancers. It is responsible for 1/3 of all cancer-related deaths. Cancer patients with cachexia live half as long as patients with the same cancers without cachexia. These emaciated patients have a poor quality of life which precludes them from receiving treatments for their respective cancer. Currently there are no effective treatments for this wasting syndrome, in part because of a lack of markers that could identify patients early in the wasting process. Therefore, clinicians often use non-approved medications for cancer cachexia with limited benefit. We therefore ...