|Awarded On||September 14, 2022|
|Title||Texas Pediatric Cancer Testing (TPCT) Core|
|Award Mechanism||Core Facility Support Awards|
|Institution/Organization||The University of Texas Health Science Center at San Antonio|
|Principal Investigator/Program Director||Peter J Houghton|
|Cancer Sites||Gallbladder, Leukemia, Liver and Intrahepatic Bile Duct, Sarcoma|
Despite some advances, the long-term disease control in many children remains elusive; improved survival has been largely driven by dose escalation and introduction of new agents, but in many survivors, these therapies are coupled to long-term life-threatening sequelae. New therapeutics are desperately needed. Increased understanding of the molecular pathology for many childhood cancers, and growing awareness that 'homogeneous' diseases are in fact heterogeneous at a molecular level provide basis for identification of agents targeted at specific molecular drivers and development of effective therapeutics. This Core will provide a service for testing new agents/combinations, against a large p...