|Awarded On||February 16, 2022|
|Title||Mechanisms of melanoma metastasis|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Sean Morrison|
Most cancer deaths are caused by distant metastasis, in which cancer cells spread to other parts of the body. Cancers that do not metastasize are almost always curable because they can be surgically removed. Yet little is known about the mechanisms that allow cancer cells to spread to other parts of the body. Distant metastasis is a very inefficient process in which most cancer cells that enter the blood die before they are able to form metastatic tumors, but it has not been understood why. We discovered that the metastasis of melanoma cells is limited by oxidative stress, caused by the generation of highly reactive molecules, called reactive oxygen species, as a result of metabolic reaction...