|Awarded On||August 18, 2021|
|Title||Single-cell proteomics to dissect intra-tumor heterogeneity|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas Health Science Center at Houston|
|Principal Investigator/Program Director||Sheng Pan|
|Cancer Sites||All Sites|
Direct measurement of unique constellations of proteins produced by single cells promises to expand our understanding of molecular cell-to-cell differences (heterogeneity) and their contribution to cellular functions in both disease and health. Mass spectrometry (MS) based single-cell proteomics represents an emerging technology for system wide, unbiased profiling of proteins in single cells or single cell clusters. Recent advances in nanoscale sample collection and processing, separation, and ionization have extended this powerful technology to meet many pressing medical challenges, such as diagnosing disease, enhancing directed stem cell differentiation, and classifying cancers. With the r...