|Awarded On||August 19, 2020|
|Title||Improving Risk Prediction for Li-Fraumeni Syndrome: A Practical Tool for Clinical Health Care Providers|
|Award Mechanism||Individual Investigator Research Awards for Prevention and Early Detection|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Banu Arun|
|Cancer Sites||Brain and Other Nervous System, Breast, Sarcoma|
Individuals with Li-Fraumeni syndrome (LFS) have increased risk of developing several cancers as children, young adults, and throughout life due to an inherited mutation in the TP53 gene. With the increased use of panel testing for patients at high risk of inheritable cancer syndromes, more individuals are seeking to understand their LFS cancer risks during genetic counseling sessions. Current surveillance recommendations for LFS consists of a rigorous regiment of multiple preventative screenings performed every six months to one year. Our objective is to improve the clinical management of individuals with a family history of early-onset cancer by evaluating the performance of mathematical m...