|Awarded On||February 19, 2020|
|Title||Molecular Mechanism of NLRP12-Mediated Regulation of Colorectal Cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Hasan Zaki|
Colorectal cancer (CRC) is the second leading cause of cancer related death in the United States. Although advanced diagnostic methods and therapeutic options significantly reduce death associated with this disease, recovery from stage III and IV of CRC remains very poor. This emphasizes the importance of investigation on the molecular mechanisms of CRC pathogenesis and identification of regulatory pathways, which can be targeted for therapeutic intervention. Genetic studies have identified several genes and pathways associated with CRC, among which most notably is the Wnt/b-catenin pathway. About 80% of CRC patients carry mutations in the Wnt/b-catenin pathway genes. Therefore, understandin...