Grant ID RP200047
Awarded On February 19, 2020
Title KRAS Spatiotemporal Dynamics: Novel Therapeutic Targets
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Health Science Center at Houston
Principal Investigator/Program Director John F Hancock
Cancer Sites Colorectal, Lung and Bronchus, Pancreas
Contracted Amount $900,000
Lay Summary

RAS is a protein that operates as a molecular switch, toggling between an active “on- state” and an inactive “off-state” in response to growth signals received by the cell. When RAS is in the “on-state” it activates a signaling network that instructs the cell to divide. Unfortunately, 15-20% of all human tumors acquire mutations that lock the RAS switch in the “on-state”. Cells with a mutant RAS switch therefore receive a constant signal to undergo cell division, resulting in the outgrowth of a tumor. The major clinical problem is with a form of RAS called KRAS that is mutated in more than 90% of pancreatic cancers, approximately 50% of colon cancers and 25% of non-small cell lung cancers. W...

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