Grant ID RP190672
Awarded On August 21, 2019
Title Alleviating SN-38-induced late-onset diarrhea by preserving local UGTs in the colon
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization Texas Southern University
Principal Investigator/Program Director Song Gao
Cancer Sites Breast, Colorectal, Pancreas
Contracted Amount $200,000
Lay Summary

Chemotherapy-induced diarrhea is a common side effect but is an understudied area in cancer management. This problem is especially significant with irinotecan, a prodrug of SN-38 used to treat metastatic colon cancer as well as other types of cancers (e.g., pancreatic cancer). It is reported that more than 80% of patients treated with irinotecan experienced diarrhea, with up to 40% of severe late-onset diarrhea. The overall goal of this project is to develop diarrheal biomarkers and develop preventive agents against irinotecan-induced diarrhea. We will perform a series of experiments using both in vitro and in vivo models to determine the feasibility of developing a probe for diarrhea predic...

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