|Awarded On||August 21, 2019|
|Title||Real-time analyses of metabolic synergy between cancer and stromal cells by optogenetic control of cell signaling|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Texas A&M University System Health Science Center|
|Principal Investigator/Program Director||Fen Wang|
|Cancer Sites||All Sites|
It has been demonstrated that cancer cells can instruct cancer associated host cells (CAFs) to provide fuels and building blocks for the rapid growth of cancer cells by reprogramming the energy metabolism of CAFs. The change in cell metabolism leads to lactate accumulation and acidification in the tumor microenvironment, both of which can compromise the effectiveness of cancer treatment. However, the lack of experimental methods that allow researchers to selectively manipulate the metabolic activity and flux of metabolites between cancer cells and CAFs in real-time manner has prevented dissecting the molecular mechanisms underlying metabolic synergy and made it difficult to evaluate the cont...