Grant ID RP190579
Awarded On August 21, 2019
Title Novel High-Throughput Microfluidic Device for Isolating T-cells Directly from Whole Blood to Simplify Manufacturing of Cellular Therapies
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization University of Houston
Principal Investigator/Program Director Sergey S Shevkoplyas
Cancer Sites All Sites
Contracted Amount $200,000
Lay Summary

The use of novel chimeric antigen receptor (CAR)-modified T-cells as a highly effective treatment for various types of cancer continues to expand. To receive a CAR T-cell treatment, cancer patients must first undergo leukapheresis, a highly specialized, expensive procedure during which 10-15 liters of patient’s blood are continuously recirculated, over several hours, through an apheresis machine to extract a sample enriched with patient’s T-cells. Because the leukapheresis sample also contains large quantities of unwanted cells that may interfere with the subsequent CAR T-cell manufacturing process, the sample is further processed via density gradient centrifugation to remove the unwanted ...

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