Grant ID DP240239
Awarded On May 15, 2024
Title Development of LILRB4 antibodies and companion precision biomarkers for patient selection to overcome myeloid-dependent resistance to T cell checkpoint therapy
Program Product Development Research
Award Mechanism Seed Awards for Product Development Research
Institution/Organization Bectas Therapeutics Inc.
Principal Investigator/Program Director Ronan O'Hagan
Cancer Sites Kidney and Renal Pelvis, Lung and Bronchus, Skin
Contracted Amount $2,750,000*

*Pending contract negotiation

Lay Summary

Despite the promise of immune-based therapies for cancer 75% - 85% of patients are not cured by existing immune therapies. Limited progress has been made in addressing the lack of response in patients who do not benefit from existing therapies. This is due largely to a lack of precise understanding of which patients will benefit from which additional therapy. We have identified myeloid cell surface receptors, including the LILRB4 protein, that suppress the immune system and drive resistance to existing therapy in 25% of patients. We have also identified a biomarker that enables precise identification of the cancer patients who will benefit from inhibition of LILRB4. We have generated a high-...

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