| Grant ID | RR230040 |
| Awarded On | August 16, 2023 |
| Title | Recruitment of First-Time, Tenure-Track Faculty Members |
| Program | CPRIT Scholar |
| Award Mechanism | Recruitment of First-Time, Tenure-Track Faculty Members |
| Institution/Organization | Baylor College of Medicine |
| Principal Investigator/Program Director | Graham Erwin |
| Cancer Sites | All Sites |
| Contracted Amount | $2,000,000 |
| Summary of Goals and Objectives |
The cancer genome is characterized by a myriad of genetic alterations that promote its growth and survival. In 5% of cancers, expansions and contractions at repetitive regions called short tandem repeat sequences lead to microsatellite instability. Although variations in TR sequences are implicated in over 40 human diseases, they remain underexplored in cancer due to the limitations of conventional bioinformatic tools. Our recent work identified recurrent repeat expansions (rREs) as an unexplored source of genetic variation in cancer (Erwin et al., Nature 2023). A comprehensive understanding of repeat variation in cancer is essential for developing novel TR-targeting therapeutics. In this a... |